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Article

Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

1 Feb 2022

Abstract excerpt

Proton radiotherapy has been implemented into the standard-of-care for cancer patients within recent years. However, experimental studies investigating cellular and molecular mechanisms are lacking, and prognostic biomarkers are needed. Cancer stem cell (CSC)-related biomarkers, such as aldehyde dehydrogenase (ALDH), are known to influence cellular radiosensitivity through inactivation of reactive oxygen species,...

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PMID: 35196495
DOI: 10.1016/j.celrep.2022.110422

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