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Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability

20 Jan 2022

Abstract excerpt

Cancer stem-like cells (CSCs) within solid tumors exhibit radioresistance, leading to recurrence and distant metastasis after radiotherapy. To experimentally study the characteristics of CSCs, radioresistant cell lines were successfully established using fractionated X-ray irradiation. The fundamental characteristics of CSCs in vitro have been previously reported; however, the relationship between CSC and...

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PMID: 35058559
DOI: 10.1038/s41598-022-05172-4

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