Article

Development of attenuated coxsackievirus B3 vectored intranasal pre-emptive pan-coronavirus vaccine

2023-11-23

Abstract excerpt

SARS-CoV-2 has the ability to evade immunity, resulting in breakthrough infections even after vaccination. Similarly, zoonotic coronaviruses pose a risk of spillover to humans. There is an urgent need to develop a pre-emptive pan-coronavirus vaccine that can induce systemic and mucosal immunity. Here, we employed a combination of immune-informatics approaches to identify shared immunodominant linear B- and T-cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f55cd9d8-fb07-5bea-9048-ce8f14dbb310
DOI: 10.1101/2023.11.22.568225

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of attenuated coxsackievirus B3 vectored intranasal pre-emptive pan-coronavirus vaccineDOI 10.1101/2023.11.22.568225Read

Evolving SARS-CoV-2 Vaccines: From Current Solutions to Broad-Spectrum ProtectionSemantic proximity Read

A pan-human coronavirus recombinant vaccine designed from conserved structural epitopes to counter emerging SARS-CoV-2 variantsSemantic proximity Read

Research progress and challenges to coronavirus vaccine developmentSemantic proximity Read

<strong>Efficacy of COVID-19 Vaccines Against the Omicron Variant of SARS-CoV-2</strong>Semantic proximity Read

Single-dose respiratory mucosal delivery of next-generation viral-vectored COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2Semantic proximity Read

Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platformSemantic proximity Read

Genome-Wide Asymptomatic B-Cell, CD4+ and CD8+ T-Cell Epitopes, that are Highly Conserved between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Immune Targets for Pre-Emptive Pan-Coronavirus VaccinesSemantic proximity Read

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2Semantic proximity Read

UB-612, a Multitope Universal Vaccine Eliciting a Balanced B and T Cell Immunity against SARS-CoV-2 Variants of ConcernSemantic proximity Read

Potential Immunogenic Activity of Computationally Designed mRNA- and Peptide-Based Prophylactic Vaccines against MERS, SARS-CoV, and SARS-CoV-2: A Reverse Vaccinology ApproachSemantic proximity Read

A review of leading COVID-19 vaccines, the quest for immune protection, and its key challenges. Part 3: Covid-19 vaccines – Key challenges and translational scienceSemantic proximity Read

Genome-Wide Asymptomatic B-Cell, CD4 <sup>+</sup> and CD8 <sup>+</sup> T-Cell Epitopes, that are Highly Conserved Between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Immune Targets for Pre-Emptive Pan-Coronavirus VaccinesSemantic proximity Read