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Article

Causal Associations of Thyroid Function and Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study.

American journal of ophthalmology - 1 Jul 2022

Li Xi, Li Hanyu, Cheng Jingdan, Wang Mengting, Zhong Yiming, Shi Guilian, Yu A-Yong

Abstract excerpt

PURPOSE: To determine whether causal association lies between thyroid function and age-related macular degeneration (AMD) risk in human beings. DESIGN: Two-sample Mendelian randomization (MR) study. METHODS: The single-nucleotide polymorphisms associated with free thyroxine (FT4) and thyroid-stimulating hormone (TSH) were selected from a genome-wide association study (GWAS) of 72,167 individuals of European...

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PMID: 35176254
DOI: 10.1016/j.ajo.2022.01.026

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