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Article

Molecular GBM versus Histopathological GBM: Radiology-Pathology-Genetic Correlation and the New WHO 2021 Definition of Glioblastoma.

AJNR. American journal of neuroradiology - 9 Aug 2024

Agarwal Amit, Edgar Mark A, Desai Amit, Gupta Vivek, Soni Neetu, Bathla Girish

Abstract excerpt

Given the recent advances in molecular pathogenesis of tumors, with better correlation with tumor behavior and prognosis, major changes were made to the new 2021 World Health Organization (WHO) classification of CNS tumors, including updated criteria for diagnosis of glioblastoma (GBM). Diagnosis of GBM now requires absence of isocitrate dehydrogenase and histone 3 mutations (IDH-wild-type and H3-wild-type) as...

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Identifiers

PMID: 38438167
DOI: 10.3174/ajnr.A8225
PMCID: PMC11383408

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