Article
The early infiltrative phase of GBM hypothesis: are molecular glioblastomas histological glioblastomas in the making? A preliminary multicenter study.
Journal of neuro-oncology - 1 Jul 2022
Ramos-Fresnedo Andres, Domingo Ricardo A, Perez-Vega Carlos, Pullen Michael W, Akinduro Oluwaseun O, Almeida Joao P, Jentoft Mark E, Bendok Bernard R, Chaichana Kaisorn L, Trifiletti Daniel M, Burns Terence C, Porter Alyx B, Kizilbash Sani H, Middlebrooks Erik H, Quiñones-Hinojosa Alfredo, Sherman Wendy J
Abstract excerpt
PURPOSE: The presence of necrosis or microvascular proliferation was previously the hallmark for glioblastoma (GBM) diagnosis. The 2021 WHO classification now considers IDH-wildtype diffuse astrocytic tumors without the histological features of glioblastoma (that would have otherwise been classified as grade 2 or 3) as molecular GBM (molGBM) if they harbor any of the following molecular abnormalities: TERT...
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