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Biallelic Variants in CFAP61 Cause Multiple Morphological Abnormalities of the Flagella and Male Infertility

31 Jan 2022

Abstract excerpt

Multiple morphological abnormalities of the flagella (MMAF) can lead to male infertility due to impaired sperm motility and morphology. Calmodulin- and spoke-associated complex (CSC) are known for their roles in radial spoke (RS) assembly and ciliary motility in Chlamydomonas, while the role of cilia- and flagella-associated protein 61 (CFAP61), a mammalian ortholog of the CSC subunits, in humans is yet unknown....

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PMID: 35174165
DOI: 10.3389/fcell.2021.803818

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Biallelic Variants in CFAP61 Cause Multiple Morphological Abnormalities of the Flagella and Male InfertilityPMID 35174165Read ↗

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