Article
Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer.
British journal of cancer - 1 Jun 2022
Patel Meera, Pennel Kathryn A F, Quinn Jean A, Hood Hannah, Chang David K, Biankin Andrew V, Rebus Selma, Roseweir Antonia K, Park James H, Horgan Paul G, McMillan Donald C, Edwards Joanne
Abstract excerpt
BACKGROUND: To understand the relationship between key non-canonical NF-κB kinase IKK-alpha(α), tumour mutational profile and survival in primary colorectal cancer. METHODS: Immunohistochemical expression of IKKα was assessed in a cohort of 1030 patients who had undergone surgery for colorectal cancer using immunohistochemistry. Mutational tumour profile was examined using a customised gene panel....
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