Article
NCOR2 is a novel candidate gene for migraine-epilepsy phenotype.
Cephalalgia : an international journal of headache - 1 Jun 2022
Nuottamo Marjo Eveliina, Häppölä Paavo, Artto Ville, Hautakangas Heidi, Pirinen Matti, Hiekkalinna Tero, Ellonen Pekka, Lepistö Maija, Hämäläinen Eija, Siren Auli, Lehesjoki Anna-Elina, Kallela Mikko, Palotie Aarno, Kaunisto Mari Anneli, Wessman Maija
Abstract excerpt
HYPOTHESIS: To identify genetic factors predisposing to migraine-epilepsy phenotype utilizing a multi-generational family with known linkage to chr12q24.2-q24.3. METHODS: We used single nucleotide polymorphism (SNP) genotyping and next-generation sequencing technologies to perform linkage, haplotype, and variant analyses in an extended Finnish migraine-epilepsy family (n = 120). In addition, we used a large...
Topics
- Epilepsy
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Migraine Disorders
- Nuclear Receptor Co-Repressor 2
- Phenotype
- Polymorphism, Single Nucleotide