Article
Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura.
Nature genetics - 1 Nov 2023
Bjornsdottir Gyda, Chalmer Mona A, Stefansdottir Lilja, Skuladottir Astros Th, Einarsson Gudmundur, Andresdottir Margret, Beyter Doruk, Ferkingstad Egil, Gretarsdottir Solveig, Halldorsson Bjarni V, Halldorsson Gisli H, Helgadottir Anna, Helgason Hannes, Hjorleifsson Eldjarn Grimur, Jonasdottir Adalbjorg, Jonasdottir Aslaug, Jonsdottir Ingileif, Knowlton Kirk U, Nadauld Lincoln D, Lund Sigrun H, Magnusson Olafur Th, Melsted Pall, Moore Kristjan H S, Oddsson Asmundur, Olason Pall I, Sigurdsson Asgeir, Stefansson Olafur A, Saemundsdottir Jona, Sveinbjornsson Gardar, Tragante Vinicius, Unnsteinsdottir Unnur, Walters G Bragi, Zink Florian, Rødevand Linn, Andreassen Ole A, Igland Jannicke, Lie Rolv T, Haavik Jan, Banasik Karina, Brunak Søren, Didriksen Maria, T Bruun Mie, Erikstrup Christian, Kogelman Lisette J A, Nielsen Kaspar R, Sørensen Erik, Pedersen Ole B, Ullum Henrik, Masson Gisli, Thorsteinsdottir Unnur, Olesen Jes, Ludvigsson Petur, Thorarensen Olafur, Bjornsdottir Anna, Sigurdardottir Gudrun R, Sveinsson Olafur A, Ostrowski Sisse R, Holm Hilma, Gudbjartsson Daniel F, Thorleifsson Gudmar, Sulem Patrick, Stefansson Hreinn, Thorgeirsson Thorgeir E, Hansen Thomas F, Stefansson Kari
Abstract excerpt
Migraine is a complex neurovascular disease with a range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine subtypes, migraine with aura (MA) and migraine without aura (MO). We identified four new MA-associated variants (in PRRT2, PALMD, ABO and LRRK2) and classified...
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