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Article

Genome-wide association analysis identifies susceptibility loci for migraine without aura.

Nature genetics - 10 Jun 2012

Freilinger Tobias, Anttila Verneri, de Vries Boukje, Malik Rainer, Kallela Mikko, Terwindt Gisela M, Pozo-Rosich Patricia, Winsvold Bendik, Nyholt Dale R, van Oosterhout Willebrordus P J, Artto Ville, Todt Unda, Hämäläinen Eija, Fernández-Morales Jèssica, Louter Mark A, Kaunisto Mari A, Schoenen Jean, Raitakari Olli, Lehtimäki Terho, Vila-Pueyo Marta, Göbel Hartmut, Wichmann Erich, Sintas Cèlia, Uitterlinden Andre G, Hofman Albert, Rivadeneira Fernando, Heinze Axel, Tronvik Erling, van Duijn Cornelia M, Kaprio Jaakko, Cormand Bru, Wessman Maija, Frants Rune R, Meitinger Thomas, Müller-Myhsok Bertram, Zwart John-Anker, Färkkilä Markus, Macaya Alfons, Ferrari Michel D, Kubisch Christian, Palotie Aarno, Dichgans Martin, van den Maagdenberg Arn M J M

Abstract excerpt

Migraine without aura is the most common form of migraine, characterized by recurrent disabling headache and associated autonomic symptoms. To identify common genetic variants associated with this migraine type, we analyzed genome-wide association data of 2,326 clinic-based German and Dutch individuals with migraine without aura and 4,580 population-matched controls. We selected SNPs from 12 loci with 2 or more...

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Identifiers

PMID: 22683712
DOI: 10.1038/ng.2307
PMCID: PMC3773912

Genes

ASTN2
LRP1
PHACTR1
TGFBR2
TRPM8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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