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Article

Upregulation of C/EBP Homologous Protein induced by ER Stress Mediates Epithelial to Myofibroblast Transformation in ADTKD-UMOD.

International journal of medical sciences - 1 Jan 2022

Wang Dan, Qiu Yagui, Fan Jinjin, Liu Yuanying, Chen Wenfang, Li Zhijian, Chen Wei, Wang Xin

Abstract excerpt

Autosomal dominant tubulointerstitial kidney disease due to UMOD mutations (ADTKD-UMOD) results in chronic interstitial nephritis, which gradually develops into end-stage renal disease. It is believed that the accumulation of mutant uromodulin causes the endoplasmic reticulum (ER) stress, then leads to the kidney damage. But the underlying mechanism remains unclear. To find the ADTKD-UMOD patients, UMOD gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35165522
DOI: 10.7150/ijms.65036
PMCID: PMC8795802

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