Article
The diagnostic value of uromodulin protein measurement in autosomal dominant tubulointerstitial kidney disease due to uromodulin mutation (ADTKD-UMOD): serum or urine?
BMC nephrology - 29 Dec 2025
Onoe Tamehito, Kawano Mitsuhiro, Mizushima Ichiro, Ito Kiyoaki, Kawahara Hiroyuki, Matsuno Takahiro, Hara Satoshi, Yamada Kazunori, Zoshima Takeshi, Goto-Hirano Keiko, Daimon Shoichiro, Muramoto Hiroaki, Ubara Yoshifumi, Mitobe Michihiro, Tsuruta Hiroaki, Kishimoto Nao, Imura Junko, Mori Takayasu, Iwata Yasunori
Abstract excerpt
BACKGROUND: Autosomal dominant tubulointerstitial kidney disease caused by uromodulin mutation (ADTKD-UMOD) is a hereditary condition characterized by progressive renal dysfunction, often requiring renal replacement therapy by middle age. A notable feature is a strong family history of chronic kidney disease (CKD) and hyperuricemia; however, the absence of urinary abnormalities often delays diagnosis. To...
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