Article
Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans.
Nature communications - 14 Feb 2022
Boua Palwende Romuald, Brandenburg Jean-Tristan, Choudhury Ananyo, Sorgho Hermann, Nonterah Engelbert A, Agongo Godfred, Asiki Gershim, Micklesfield Lisa, Choma Solomon, Gómez-Olivé Francesc Xavier, Hazelhurst Scott, Tinto Halidou, Crowther Nigel J, Mathew Christopher G, Ramsay Michèle
Abstract excerpt
Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 to 60 years) resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new...
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