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Article

The role of the conserved COOH-terminal triad in alphaA-crystallin aggregation and functionality.

Molecular vision - 19 Sept 2007

Li Ying, Schmitz Karl R, Salerno John C, Koretz Jane F

Abstract excerpt

PURPOSE: The sequentially variable COOH-terminal region of small heat shock protein superfamily members usually contains a conserved IXI/V feature where X is typically a proline. When present in solved sHsp crystal structures (e.g. MjHsp16.5 and wheat Hsp16.9), this short sequence forms an isolated beta strand apparently involved in the alignment of dimers into larger oligomers. Because it is a common feature of...

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PMID: 17960114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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