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Article

Quantitative in vitro and in vivo characterization of the human P32T mutant ITPase.

Biochimica et biophysica acta - 1 Feb 2010

Herting Greg, Barber Katie, Zappala Maria R, Cunningham Richard P, Burgis Nicholas E

Abstract excerpt

Human ITPase, encoded by the ITPA gene, and its orthologs (RdgB in Escherichia coli and HAM1 in Saccharomyces cerevisiae) exclude noncanonical nucleoside triphosphates (NTPs) from NTP pools. Deoxyinosine triphosphate (dITP) and 2'-deoxy-N-6-hydroxylaminopurine triphosphate are both hydrolyzed by ITPase to yield the corresponding deoxynucleoside monophosphate and pyrophosphate. In addition, metabolites of...

Topics

Amino Acid Substitution
Blotting, Western
Escherichia coli
Genes, Lethal
Genetic Complementation Test
Genotype
Humans
Kinetics
Plasmids
Polymorphism, Single Nucleotide
Pyrophosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Proteins

Substrate Specificity

Inosine Triphosphatase

Source

Open in PubMed Open full text

Identifiers

PMID: 19914375
DOI: 10.1016/j.bbadis.2009.11.002
PMCID: PMC2818573

Genes

ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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