Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid detection of multiple SARS-CoV-2 variants of concern by PAM-targeting mutations.

Cell reports methods - 28 Feb 2022

Ning Bo, Youngquist Brady M, Li Diane D, Lyon Christopher J, Zelazny Adrian, Maness Nicholas J, Tian Di, Hu Tony Y

Abstract excerpt

SARS-CoV-2 variants of concern (VOCs) that increase transmission or disease severity or reduce diagnostic or vaccine efficacy continue to emerge across the world. Current methods available to rapidly detect these can be resource intensive and thus sub-optimal for large-scale deployment needed during a pandemic response. Here, we describe a CRISPR-based assay that detects mutations in spike gene CRISPR PAM motif...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Assay
Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR and Genetic Engineering

Share to Mutation

Share to SARS-CoV-2

Share to SARS-CoV-2 and COVID-19 Research

Share to SARS-CoV-2 detection and testing

Source

Open in PubMed Open full text

Identifiers

PMID: 35156077
DOI: 10.1016/j.crmeth.2022.100173
PMCID: PMC8818353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid detection of multiple SARS-CoV-2 variants of concern by PAM-targeting mutations.PMID 35156077Read ↗

CRISPR-Cas12a-Based Detection for the Major SARS-CoV-2 Variants of Concern.Semantic proximity Read ↗

COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 EnzymeSemantic proximity Read ↗

VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillanceSemantic proximity Read ↗

CRISPR-based molecular detection of SARS-CoV-2, its emerging variants, and diverse pathogensSemantic proximity Read ↗

COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme.Semantic proximity Read ↗

Rapid and accurate detection of SARS-CoV-2 mutations using a Cas12a-based sensing platform.Semantic proximity Read ↗

Advancing Sewage Sample Surveillance with OmiCrisp: A CRISPR-Based Platform for Variant-Specific SARS-CoV-2 DetectionSemantic proximity Read ↗

Highly Sensitive Detection Method for HV69-70del in SARS-CoV-2 Alpha and Omicron Variants Based on CRISPR/Cas13aSemantic proximity Read ↗

A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant SurveillanceSemantic proximity Read ↗

Detection of Major SARS-CoV-2 Variants of Concern in Clinical Samples via CRISPR-Cas12a-Mediated Mutation-Specific Assay.Semantic proximity Read ↗

Targeted Hybridization Capture of SARS-CoV-2 and Metagenomics Enables Genetic Variant Discovery and Nasal Microbiome Insights.Semantic proximity Read ↗

A rapid point-of-care population-scale dipstick assay to identify and differentiate SARS-CoV-2 variants in COVID-19-positive patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.