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Article

Detection of Major SARS-CoV-2 Variants of Concern in Clinical Samples via CRISPR-Cas12a-Mediated Mutation-Specific Assay.

ACS synthetic biology - 20 May 2022

Liang Yuanhao, Zou Lirong, Lin Hongqing, Li Baisheng, Zhao Jianhui, Wang Haiying, Sun Jiufeng, Chen Jingdiao, Mo Yanling, Yang Xingfen, Deng Xiaoling, Tang Shixing

Abstract excerpt

Objectives: Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants pose a great threat and burden to global public health. Here, we evaluated a clustered regularly interspaced short palindromic repeat-associated enzyme 12a (CRISPR-Cas12a)-based method for detecting major SARS-CoV-2 variants of concern (VOCs) in SARS-CoV-2 positive clinical samples. Methods: Allele-specific CRISPR RNAs...

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Identifiers

PMID: 35481381
DOI: 10.1021/acssynbio.1c00643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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