Article
Targeted Hybridization Capture of SARS-CoV-2 and Metagenomics Enables Genetic Variant Discovery and Nasal Microbiome Insights.
Microbiology spectrum - 31 Oct 2021
Nagy-Szakal Dorottya, Couto-Rodriguez Mara, Wells Heather L, Barrows Joseph E, Debieu Marilyne, Butcher Kristin, Chen Siyuan, Berki Agnes, Hager Courteny, Boorstein Robert J, Taylor Mariah K, Jonsson Colleen B, Mason Christopher E, O'Hara Niamh B
Abstract excerpt
The emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic variants that may alter viral fitness highlights the urgency of widespread next-generation sequencing (NGS) surveillance. To profile genetic variants of the entire SARS-CoV-2 genome, we developed and clinically validated a hybridization capture SARS-CoV-2 NGS assay, integrating novel methods for panel design using...
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