Article
COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme.
Journal of clinical microbiology - 20 Jul 2022
Fasching Clare L, Servellita Venice, McKay Bridget, Nagesh Vaishnavi, Broughton James P, Sotomayor-Gonzalez Alicia, Wang Baolin, Brazer Noah, Reyes Kevin, Streithorst Jessica, Deraney Rachel N, Stanfield Emma, Hendriks Carley G, Fung Becky, Miller Steve, Ching Jesus, Chen Janice S, Chiu Charles Y
Abstract excerpt
Laboratory tests for the accurate and rapid identification of SARS-CoV-2 variants can potentially guide the treatment of COVID-19 patients and inform infection control and public health surveillance efforts. Here, we present the development and validation of a rapid COVID-19 variant DETECTR assay incorporating loop-mediated isothermal amplification (LAMP) followed by CRISPR-Cas12 based identification of single...
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