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Improving the cell-membrane-penetrating activity of globins by introducing positive charges on protein surface: A case study of sperm whale myoglobin.

Biochemical and biophysical research communications - 2 Apr 2022

Gao Shu-Qin, Yuan Hong, Yang Xin-Zhi, Xiang Heng-Fang, Tan Xiangshi, Wen Ge-Bo, Lin Ying-Wu

Abstract excerpt

Globins are heme proteins such as hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb), playing important roles in biological system. In addition to normal functions, zebrafish Ngb was able to penetrate cell membranes, whereas less was known for other globin members. In this study, to improve the cell-membrane-penetrating activity of globins, we used sperm whale Mb as a model protein and constructed a quadruple...

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PMID: 35151200
DOI: 10.1016/j.bbrc.2022.02.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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