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Article

Biallelic mutations in cancer genomes reveal local mutational determinants.

Nature genetics - 1 Feb 2022

Demeulemeester Jonas, Dentro Stefan C, Gerstung Moritz, Van Loo Peter

Abstract excerpt

The infinite sites model of molecular evolution posits that every position in the genome is mutated at most once1. By restricting the number of possible mutation histories, haplotypes and alleles, it forms a cornerstone of tumor phylogenetic analysis2 and is often implied when calling, phasing and interpreting variants3,4 or studying the mutational landscape as a whole5. Here we identify 18,295 biallelic...

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Identifiers

PMID: 35145300
DOI: 10.1038/s41588-021-01005-8
PMCID: PMC8837546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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