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Article

HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer

10 Feb 2022

Abstract excerpt

BACKGROUND: Head and Neck cancer (HNC) is a fatal malignancy with poor prognosis. Human Papillomavirus (HPV) infection is becoming the prominent cause of HNC in the western world, and studying the molecular mechanisms underlying its action in cancers is key towards targeted therapy. To replicate, HPV regulates the host DNA damage repair (DDR) pathway. SMAD4 is also involved in the regulation of the DDR machinery...

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PMID: 35144669
DOI: 10.1186/s13046-022-02258-9

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