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Article

Deciphering Bordetella pertussis epidemiology through culture-independent multiplex amplicon and metagenomic sequencing.

Journal of clinical microbiology - 11 Dec 2024

Luu Laurence Don Wai, Rafique Raisa, Payne Michael, Octavia Sophie, Robson Jennifer, Sintchenko Vitali, Lan Ruiting

Abstract excerpt

Whooping cough (pertussis) has re-emerged despite high vaccine coverage in Australia and many other countries worldwide, partly attributable to genetic adaptation of the causative organism, Bordetella pertussis, to vaccines. Therefore, genomic surveillance has become essential to monitor circulating strains for these genetic changes. However, increasing uptake of PCR for the diagnosis of pertussis has affected...

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Identifiers

PMID: 39494864
DOI: 10.1128/jcm.01178-24
PMCID: PMC11633092

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