Article
Dose-Response of a Norovirus GII.2 Controlled Human Challenge Model Inoculum.
The Journal of infectious diseases - 11 Nov 2022
Rouphael Nadine, Beck Allison, Kirby Amy E, Liu Pengbo, Natrajan Muktha S, Lai Lilin, Phadke Varun, Winston Juton, Raabe Vanessa, Collins Matthew H, Girmay Tigisty, Alvarez Alicarmen, Beydoun Nour, Karmali Vinit, Altieri-Rivera Joanne, Lindesmith Lisa C, Anderson Evan J, Wang Yuke, El-Khorazaty Jill, Petrie Carey, Baric Ralph S, Baqar Shahida, Moe Christine L, Mulligan Mark J
Abstract excerpt
BACKGROUND: Genogroup II noroviruses are the most common cause of acute infectious gastroenteritis. We evaluated the use of a new GII.2 inoculum in a human challenge. METHODS: Forty-four healthy adults (36 secretor-positive and 8 secretor-negative for histo-blood group antigens) were challenged with ascending doses of a new safety-tested Snow Mountain virus (SMV) GII.2 norovirus inoculum (1.2 × 104 to 1.2 × 107...
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