Article
Variation in Severity of Symptoms Associated With Two Snow Mountain Virus Inocula.
Journal of medical virology - 1 Aug 2025
Qu Hongyan, Rouphael Nadine, Mulligan Mark, Wang Yuke, Sablon Orlando, Moe Christine L, Liu Pengbo
Abstract excerpt
Snow Mountain Virus (SMV), the prototype of genogroup II and genotype II Norovirus (NoV), was used in human challenge studies to examine the infectivity, pathogenicity, and immune response to NoV. Clinical and laboratory data from two previously completed SMV human challenge trials using two different inocula (primary and secondary) were analyzed to compare the infectivity, illness, viral shedding, and serum IgG...
Read the complete abstract on PubMedTopics
- Humans
- Caliciviridae Infections
- Virus Shedding
- Gastroenteritis
- Norovirus
- Severity of Illness Index