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Article

Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants.

Nature communications - 8 Feb 2022

Saville James W, Mannar Dhiraj, Zhu Xing, Srivastava Shanti S, Berezuk Alison M, Demers Jean-Philippe, Zhou Steven, Tuttle Katharine S, Sekirov Inna, Kim Andrew, Li Wei, Dimitrov Dimiter S, Subramaniam Sriram

Abstract excerpt

The Delta and Kappa variants of SARS-CoV-2 co-emerged in India in late 2020, with the Delta variant underlying the resurgence of COVID-19, even in countries with high vaccination rates. In this study, we assess structural and biochemical aspects of viral fitness for these two variants using cryo-electron microscopy (cryo-EM), ACE2-binding and antibody neutralization analyses. Both variants demonstrate escape of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35136050
DOI: 10.1038/s41467-022-28324-6
PMCID: PMC8826856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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