Article
Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality.
PloS one - 1 Jan 2022
Shawer Heba, Cheng Chew W, Bailey Marc A
Abstract excerpt
The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia. Whether ORAI1 itself is associated with an increased risk for severe COVID-19 presentation is still unknown. Here, we employed genetic association analysis to investigate...
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