A highly virulent variant of HIV-1 circulating in the Netherlands.

doi:10.1126/science.abk1688

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Article

A highly virulent variant of HIV-1 circulating in the Netherlands.

Science (New York, N.Y.) - 4 Feb 2022

Wymant Chris, Bezemer Daniela, Blanquart François, Ferretti Luca, Gall Astrid, Hall Matthew, Golubchik Tanya, Bakker Margreet, Ong Swee Hoe, Zhao Lele, Bonsall David, de Cesare Mariateresa, MacIntyre-Cockett George, Abeler-Dörner Lucie, Albert Jan, Bannert Norbert, Fellay Jacques, Grabowski M Kate, Gunsenheimer-Bartmeyer Barbara, Günthard Huldrych F, Kivelä Pia, Kouyos Roger D, Laeyendecker Oliver, Meyer Laurence, Porter Kholoud, Ristola Matti, van Sighem Ard, Berkhout Ben, Kellam Paul, Cornelissen Marion, Reiss Peter, Fraser Christophe

Abstract excerpt

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with...

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Identifiers

PMID: 35113714
DOI: 10.1126/science.abk1688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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