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Article

Compound screening identified gossypetin and isoquercitrin as novel inhibitors for amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis.

Biochemical and biophysical research communications - 12 Mar 2022

Takahashi Daisuke, Matsunaga Eri, Yamashita Tomohiro, Caaveiro Jose M M, Abe Yoshito, Ueda Tadashi

Abstract excerpt

AL amyloidosis is a life-threatening disease characterized by the deposition of amyloidogenic immunoglobulin light chain secreted from clonal plasma cells. Here we established an in-vitro screening system of amyloid inhibition of a variable domain in λ6 light chain mutant (Vλ6), Wil, and screened a food-additive compound library to identify compounds inhibiting the fibril formation. We found gossypetin and...

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Identifiers

PMID: 35108650
DOI: 10.1016/j.bbrc.2022.01.066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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