Patient-specific genetic factors predict treatment failure in sofosbuvir-treated patients with chronic hepatitis C.

doi:10.1111/liv.15175

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Article

Patient-specific genetic factors predict treatment failure in sofosbuvir-treated patients with chronic hepatitis C.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2022

Loucks Catrina M, Lin Jennifer J, Trueman Jessica N, Drögemöller Britt I, Wright Galen E B, Chang Wan-Chun, Li Kathy H, Yoshida Eric M, Ford Jo-Ann, Lee Samuel S, Crotty Pam, Kim Richard B, Al-Judaibi Bandar, Schwarz Ute I, Ramji Alnoor, Farivar Jeanette F, Tam Edward, Walston Lori Lee, Ross Colin J D, Carleton Bruce C

Abstract excerpt

BACKGROUND & AIMS: According to pivotal clinical trials, cure rates for sofosbuvir-based antiviral therapy exceed 96%. Treatment failure is usually assumed to be because of virological resistance-associated substitutions or clinical risk factors, yet the role of patient-specific genetic factors has not been well explored. We determined if patient-specific genetic factors help predict patients likely to fail...

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Identifiers

PMID: 35107877
DOI: 10.1111/liv.15175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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