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Article

Association of mutations in DNA polymerase epsilon with increased CD8+ cell infiltration and prolonged progression-free survival in patients with meningiomas.

Neurosurgical focus - 1 Feb 2022

Rutland John W, Dullea Jonathan T, Gill Corey M, Chaluts Danielle, Ranti Daniel, Ellis Ethan, Arrighi-Allisan Annie, Kinoshita Yayoi, McBride Russell B, Bederson Joshua, Donovan Michael, Sebra Robert, Fowkes Mary, Umphlett Melissa, Shrivastava Raj K

Abstract excerpt

OBJECTIVE: Prior studies have demonstrated a relationship between underlying tumor genetics and lymphocyte infiltration in meningiomas. In this study, the authors aimed to further characterize the relationship between meningioma genomics, CD4+ and CD8+ T-cell infiltration, and oncological outcomes of meningiomas. Understanding specific characteristics of the inflammatory infiltration could have implications for...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Meningeal Neoplasms

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Source

Identifiers

PMID: 35104796
DOI: 10.3171/2021.11.FOCUS21592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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