Article
NF2 mutation status and tumor mutational burden correlate with immune cell infiltration in meningiomas.
Cancer immunology, immunotherapy : CII - 1 Jan 2021
Rutland John W, Gill Corey M, Loewenstern Joshua, Arib Hanane, Pain Margaret, Umphlett Melissa, Kinoshita Yayoi, McBride Russell B, Bederson Joshua, Donovan Michael, Sebra Robert, Shrivastava Raj K, Fowkes Mary
Abstract excerpt
BACKGROUND: The tumor microenvironment is an emerging biomarker of underlying genomic heterogeneity and response to immunotherapy-based treatment regimens in solid malignancies. How tumor mutational burden influences the density, distribution, and presence of a localized immune response in meningiomas is unknown. METHODS: Representative hematoxylin and eosin slides were reviewed at 40X to assess for the density...
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