Article
Establishment and characterization of human induced pluripotent stem cell line from a Parkinson's disease patient harboring VPS13A gene mutation.
Stem cell research - 1 Apr 2022
Lu Xianjie, Wang Wei, Liu Yanming, Song Na, Li Mengpeng, Mu Xin, Zhang Nan, Chen Qingfa, Jiang Licheng, Kong Xianglin, Sun Peng, Tong Jiabei, Zhang Yunping, Li Jingtao, Ma Shengjun, Han Fabin
Abstract excerpt
Mutations in VPS13 gene have been recently reported as a genetic cause of Parkinson's disease (PD). In this study, we isolated the skin fibroblasts from a PD patient harboring VPS13A gene mutation (c. 4282_4289delinsA) and reprogrammed the fibroblasts to a novel patient-specific induced pluripotent stem cell (iPSC) line LCPHi002-A using transgene-free episomal plasmids to express OCT3/4, SOX2, KLF4, L-MYC, and...
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