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Generation of an induced pluripotent stem cell line, FJMUUHi001-A, from a hereditary Parkinson's disease patient with homozygous mutation of c.189dupA in PARK7.

Stem cell research - 1 Mar 2021

Chen Zhi-Ting, Zhao Zhen-Hua, Chen Li-Na, Fan Fei, Cai Guo-En, Weng Hui-Dan, Wang Ying-Qing, Liao Lian-Ming, Chen Xiao-Chun, Huang En, Ye Qin-Yong

Abstract excerpt

PARK7 mutations are accountable for the inherited Parkinson's disease. An induced pluripotent stem cell (iPSC) line FJMUUHi001-A was generated by expressing five reprogramming factors, OCT3/4, SOX2, c-MYC, KLF4 and BCL-XL, in peripheral blood mononuclear cells from a 32-year old patient carrying a homozygous mutation of c.189dupA in PARK7. The iPSCs with a normal karyotype had the abilities to differentiate into...

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PMID: 33485186
DOI: 10.1016/j.scr.2021.102175

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Generation of an induced pluripotent stem cell line, FJMUUHi001-A, from a hereditary Parkinson's disease patient with homozygous mutation of c.189dupA in PARK7.PMID 33485186Read ↗

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