Article
Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid.
Biochemical and biophysical research communications - 5 Mar 2022
Harada Naoki, Arahori Yumi, Okuyama Mai, Luis Paula B, Joseph Akil I, Kitakaze Tomoya, Goshima Naoki, Schneider Claus, Inui Hiroshi, Yamaji Ryoichi
Abstract excerpt
Curcumin is a yellow pigment in turmeric (Curcuma longa) with various physiological effects in the body. To elucidate the molecular mechanisms by which bioactive compounds exert their function, identification of their molecular targets is crucial. In this study, we show that curcumin activates G protein-coupled receptor 97 (GPR97). Curcumin dose-dependently activated serum-response element-, but not...
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