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Article

The FLT3 internal tandem duplication mutation at disease diagnosis is a negative prognostic factor in myelodysplastic syndrome patients.

Leukemia research - 1 Feb 2022

Sumiyoshi Ritsu, Tashiro Haruko, Shirasaki Ryosuke, Matsuo Takuji, Yamamoto Tadashi, Matsumoto Kensuke, Ooi Jun, Shirafuji Naoki

Abstract excerpt

The role of the FMS-like tyrosine kinase 3 (FLT3) gene in acute myeloid leukemia (AML) has been well documented and the FLT3-internal tandem duplication (FLT3-ITD) mutation has been identified as a prognostic factor in AML. Due to its low incidence, the role of the FLT3 mutation remains unclear in myelodysplastic syndrome (MDS) patients. To investigate the impact of the FLT3-ITD status on the prognosis of MDS at...

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Identifiers

PMID: 35092883
DOI: 10.1016/j.leukres.2022.106790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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