Article
Let-7i-5p promotes a malignant phenotype in nasopharyngeal carcinoma via inhibiting tumor-suppressive autophagy.
Cancer letters - 10 Apr 2022
You Bo, Zhang Panpan, Gu Miao, Yin Haimeng, Fan Yue, Yao Hui, Pan Si, Xie Haijing, Cheng Tianyi, Liu Huiting, You Yiwen, Liu Jisheng
Abstract excerpt
MicroRNAs (miRNAs) regulate gene expression to participate in carcinogenesis and tumor progression. Therefore, identification of a malignant phenotype associated with miRNAs and therapeutic targets will contribute substantially in improving nasopharyngeal carcinoma (NPC) treatment. In this study, we demonstrated that overexpression of let-7i-5p promotes the malignant phenotype by acting as an autophagy suppressor...
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