Article
MIR106A-5p upregulation suppresses autophagy and accelerates malignant phenotype in nasopharyngeal carcinoma.
Autophagy - 1 Jul 2021
Zhu Qingwen, Zhang Qicheng, Gu Miao, Zhang Kaiwen, Xia Tian, Zhang Siyu, Chen Wenhui, Yin Haimeng, Yao Hui, Fan Yue, Pan Si, Xie Haijing, Liu Huiting, Cheng Tianyi, Zhang Panpan, Zhang Ting, You Bo, You Yiwen
Abstract excerpt
Dysregulated microRNAs (miRNAs) are involved in carcinoma progression, metastasis, and poor prognosis. We demonstrated that in nasopharyngeal carcinoma (NPC), transactivated MIR106A-5p promotes a malignant phenotype by functioning as a macroautophagy/autophagy suppressor by targeting BTG3 (BTG anti-proliferation factor 3) and activating autophagy-regulating MAPK signaling. MIR106A-5p expression was markedly...
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