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Article

Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2022

George Suzanne, von Mehren Margaret, Fletcher Jonathan A, Sun Jichao, Zhang Sen, Pritchard Justin R, Hodgson John Graeme, Kerstein David, Rivera Victor M, Haluska Frank G, Heinrich Michael C

Abstract excerpt

PURPOSE: The purpose of this study is to evaluate ponatinib for advanced gastrointestinal stromal tumors (GIST). PATIENTS AND METHODS: This single-arm phase II trial enrolled patients with metastatic and/or unresectable GIST with failure of prior tyrosine kinase inhibitor (TKI) treatment into two cohorts based on presence or absence of KIT exon 11 (ex11) primary mutations. Patients initially received ponatinib 45...

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Identifiers

PMID: 35091442
DOI: 10.1158/1078-0432.CCR-21-2037
PMCID: PMC9531534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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