The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.

doi:10.1016/j.abb.2022.109124

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Article

The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.

Archives of biochemistry and biophysics - 15 Mar 2022

Hassan Sk Sarif, Choudhury Pabitra Pal, Dayhoff Guy W, Aljabali Alaa A A, Uhal Bruce D, Lundstrom Kenneth, Rezaei Nima, Pizzol Damiano, Adadi Parise, Lal Amos, Soares Antonio, Mohamed Abd El-Aziz Tarek, Brufsky Adam M, Azad Gajendra Kumar, Sherchan Samendra P, Baetas-da-Cruz Wagner, Takayama Kazuo, Serrano-Aroca Ãngel, Chauhan Gaurav, Palu Giorgio, Mishra Yogendra Kumar, Barh Debmalya, Santana Silva Raner Jośe, Andrade Bruno Silva, Azevedo Vasco, Góes-Neto Aristóteles, Bazan Nicolas G, Redwan Elrashdy M, Tambuwala Murtaza, Uversky Vladimir N

Abstract excerpt

The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR...

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Identifiers

PMID: 35085577
DOI: 10.1016/j.abb.2022.109124
PMCID: PMC8785432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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