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Functional analysis of a novel MHC-Iα genotype in orange-spotted grouper: Effects on Singapore grouper iridovirus (SGIV) replication and apoptosis.

Fish & shellfish immunology - 1 Feb 2022

Chen Jinpeng, Wang Liqun, Huang Jianling, Li Xinshuai, Guan Lingfeng, Wang Qing, Yang Min, Qin Qiwei

Abstract excerpt

The classical major histocompatibility complex class I (MHC-Ⅰ) molecule plays a key role in vertebrate immune response for its important functions in antigen presentation and immune regulation. MHC pathway is closely related to many diseases involving autoimmunity, antigen intrusion and inflammation. However, rare literatures about the effect of MHC-I on fish cells apoptosis were reported. In this study, a novel...

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PMID: 35077868
DOI: 10.1016/j.fsi.2022.01.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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