Article
Sex-specific splicing of Z- and W-borne nr5a1 alleles suggests sex determination is controlled by chromosome conformation.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2022
Zhang Xiuwen, Wagner Susan, Holleley Clare E, Deakin Janine E, Matsubara Kazumi, Deveson Ira W, O'Meally Denis, Patel Hardip R, Ezaz Tariq, Li Zhao, Wang Chexu, Edwards Melanie, Graves Jennifer A Marshall, Georges Arthur
Abstract excerpt
Pogona vitticeps has female heterogamety (ZZ/ZW), but the master sex-determining gene is unknown, as it is for all reptiles. We show that nr5a1 (Nuclear Receptor Subfamily 5 Group A Member 1), a gene that is essential in mammalian sex determination, has alleles on the Z and W chromosomes (Z-nr5a1 and W-nr5a1), which are both expressed and can recombine. Three transcript isoforms of Z-nr5a1 were detected in gonads...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.