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Article

A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs.

Genetics - 9 Feb 2021

Yan Yi-Lin, Titus Tom, Desvignes Thomas, BreMiller Ruth, Batzel Peter, Sydes Jason, Farnsworth Dylan, Dillon Danielle, Wegner Jeremy, Phillips Jennifer B, Peirce Judy, Dowd John, Buck Charles Loren, Miller Adam, Westerfield Monte, Postlethwait John H

Abstract excerpt

People with NR5A1 mutations experience testicular dysgenesis, ovotestes, or adrenal insufficiency, but we do not completely understand the origin of this phenotypic diversity. NR5A1 is expressed in gonadal soma precursor cells before expression of the sex-determining gene SRY. Many fish have two co-orthologs of NR5A1 that likely partitioned ancestral gene subfunctions between them. To explore ancestral roles of...

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Identifiers

PMID: 33724412
DOI: 10.1093/genetics/iyaa030
PMCID: PMC8045690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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