Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 positively regulates the expression of cancer stem cell marker CD133 in HCT116 colon cancer cells

2 May 2018

Abstract excerpt

Colon cancer stem cells (CSCs), which are highly capable of self‑renewal and proliferation, are involved in colon tumorigenesis and response to therapy. CD133 is considered the most robust surface marker for colorectal cancer stem cells. Although the TP53 gene is frequently mutated in colon cancer, it remains not fully understood whether and how tumor protein p53 (p53) is associated with CD133 expression in colon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Research and Treatments
Share to Metastasis and carcinoma case studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29928431
DOI: 10.3892/ol.2018.8619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 positively regulates the expression of cancer stem cell marker CD133 in HCT116 colon cancer cellsPMID 29928431Read ↗

CD133: A cancer stem cells marker, is used in colorectal cancersSemantic proximity Read ↗

Deficient or R273H and R248W Mutations of p53 Promote Chemoresistance to 5-FU via TCF21/CD44 Axis-Mediated Enhanced Stemness in Colorectal CarcinomaSemantic proximity Read ↗

P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAsSemantic proximity Read ↗

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markersSemantic proximity Read ↗

Characteristics of CD133 <sup>+</sup> Human Colon Cancer SW620 CellsSemantic proximity Read ↗

Expression of CD133 correlates with differentiation of human colon cancer cells.Semantic proximity Read ↗

CD133 as a target for colon cancerSemantic proximity Read ↗

TP53 Mutation by CRISPR System Enhances the Malignant Potential of Colon CancerSemantic proximity Read ↗

Characterization of colon cancer cells: a functional approach characterizing CD133 as a potential stem cell markerSemantic proximity Read ↗

CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients.Semantic proximity Read ↗

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activationSemantic proximity Read ↗

CD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.