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Article

Discovery of indirubin-3'-aminooxy-acetamide derivatives as potent and selective FLT3/D835Y mutant kinase inhibitors for acute myeloid leukemia.

European journal of medicinal chemistry - 5 Jul 2022

Lee Je-Heon, Shin Ji Eun, Kim WooChan, Jeong Pyeonghwa, Kim Myung Jin, Oh Su Jin, Lee Hyo Jeong, Park Hyun Woo, Han Sun-Young, Kim Yong-Chul

Abstract excerpt

Mutations in Fms-like tyrosine kinase 3 (FLT3) have been implicated in the pathogenesis of acute myeloid leukemia (AML) by affecting the proliferation and differentiation of hematopoietic stem and progenitor cells. Although several FLT3 inhibitors have been developed, the occurrence of secondary TKD mutations of FLT3 such FLT3/D835Y and FLT3/F691L lead to drug resistance and has become a key area of unmet medical...

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PMID: 35489222
DOI: 10.1016/j.ejmech.2022.114356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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