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Article

Whole-chromosome arm acquired uniparental disomy in cancer development is a consequence of isochromosome formation.

Neoplasia (New York, N.Y.) - 1 Mar 2022

Tuna Musaffe, Amos Christopher I, Mills Gordon B

Abstract excerpt

Using SNP-based microarray data from The Cancer Genome Atlas (TCGA), we investigated isochromosomes (deletion of one arm and duplication of the other arm) and related acquired uniparental disomy in 12 tumor types. We observed a high frequency of isochromosomes (25.98%) across all type of tumors except thyroid cancers. The highest frequency of isochromosomes was found in lung squamous cell carcinoma (54.18%)....

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Identifiers

PMID: 35065533
DOI: 10.1016/j.neo.2021.12.009
PMCID: PMC8788198

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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