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Article

TDP-43 Cytoplasmic Translocation in the Skin Fibroblasts of ALS Patients

8 Jan 2022

Abstract excerpt

Diagnosis of ALS is based on clinical symptoms when motoneuron degeneration is significant. Therefore, new approaches for early diagnosis are needed. We aimed to assess if alterations in appearance and cellular localization of cutaneous TDP-43 may represent a biomarker for ALS. Skin biopsies from 64 subjects were analyzed: 44 ALS patients, 10 healthy controls (HC) and 10 neurological controls (NC) (Parkinson’s...

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PMID: 35053327
DOI: 10.3390/cells11020209

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