Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maternal effect genes: Update and review of evidence for a link with birth defects

19 Oct 2021

Abstract excerpt

Maternal effect genes (MEGs) encode factors (e.g., RNA) that are present in the oocyte and required for early embryonic development. Hence, while these genes and gene products are of maternal origin, their phenotypic consequences result from effects on the embryo. The first mammalian MEGs were identified in the mouse in 2000 and were associated with early embryonic loss in the offspring of homozygous null...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35047854
DOI: 10.1016/j.xhgg.2021.100067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maternal effect genes: Update and review of evidence for a link with birth defectsPMID 35047854Read ↗

Maternal Effect Mutations: A Novel Cause for Human Reproductive FailureSemantic proximity Read ↗

The Human Intolerome: a curated database to prioritize genomic variants in stillbirth, pregnancy loss, and neonatal deathSemantic proximity Read ↗

The Human Intolerome: A curated database to prioritize genomic variants in stillbirth, pregnancy loss, and neonatal death.Semantic proximity Read ↗

Genetics and Stillbirth.Semantic proximity Read ↗

Rare congenital disorders, imprinted genes, and assisted reproductive technologySemantic proximity Read ↗

Genomic imprinting and its relevance to congenital disease, infertility, molar pregnancy and induced pluripotent stem cellSemantic proximity Read ↗

Gene discovery informatics toolkit defines candidate genes for unexplained infertility and prenatal or infantile mortalitySemantic proximity Read ↗

Preconception Genetic Carrier Screening for Miscarriage Risk Assessment: A Bioinformatic Approach to Identifying Candidate Lethal Genes and VariantsSemantic proximity Read ↗

Maternal variants in NLRP and other maternal effect proteins are associated with multilocus imprinting disturbance in offspringSemantic proximity Read ↗

Fetal de novo mutations and preterm birthSemantic proximity Read ↗

Genetic mechanisms of fertilization failure and early embryonic arrest: a comprehensive review.Semantic proximity Read ↗

Miscarriage risk assessment: a bioinformatic approach to identifying candidate lethal genes and variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.