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Article

Maternal variants in NLRP and other maternal effect proteins are associated with multilocus imprinting disturbance in offspring

24 Mar 2018

Abstract excerpt

Background Genomic imprinting results from the resistance of germline epigenetic marks to reprogramming in the early embryo for a small number of mammalian genes. Genetic, epigenetic or environmental insults that prevent imprints from evading reprogramming may result in imprinting disorders, which impact growth, development, behaviour and metabolism. We aimed to identify genetic defects causing imprinting...

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Share to Assisted Reproductive Technology and Twin Pregnancy
Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting

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PMID: 29574422
DOI: 10.1136/jmedgenet-2017-105190

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